Duphaston 10mg

Description

Medicine: Duphaston

Generic name: Dydrogesterone

What is the most important thing I should know about Duphaston?

• Dydrogesterone is an orally active progestogen that acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus.
• At therapeutic levels, dydrogesterone has no contraceptive effect because it does not inhibit or interfere with ovulation or the corpus luteum.
• Duphaston is non-androgenic, non-estrogenic, non-corticoid, non-anabolic and is not excreted as pregnanediol.

What is Duphaston?

Duphaston is used to treat irregular cycle length and irregular onset and duration of periods caused by progesterone deficiency.

Combined with an estrogenic substance, Duphaston can be applied in secondary amenorrhea, dysfunctional uterine bleeding and post-menopausal complaints where endogenous progesterone deficiency is involved.

What should I discuss with my doctor before taking Duphaston?

• Duphaston should not be administered to patients with undiagnosed vaginal bleeding or those with a history of thromboembolic disorders.
• Use with caution in patients with cardiovascular, renal or hepatic insufficiency, diabetes mellitus, asthma, epilepsy and migraine.
• Should be used with caution in people with a history of mental depression.

How should I take Duphaston?

The dosage regimens below are general recommendations. For optimal therapeutic effect, doses should be tailored to the nature and severity of the disorder.

• In irregular cycles due to endogenous progesterone deficiency: Duphaston 5 to 10 mg is recommended, especially in irregular cycles due to a shortened luteal phase (before menopause). Treatment should be repeated for several cycles.
• In secondary amenorrhea: Administration of Duphaston in combination with estrogen. 0.05 mg of ethinylestradiol daily is recommended from day 1 to day 25 of the cycle, and 5 mg of Duphaston twice daily from day 11 to day 25. Five days after the withdrawal bleed, the cycle is repeated to mimic a natural cycle.
• In dysfunctional uterine bleeding: To stop bleeding, Duphaston 10 mg with 0.10 mg ethinylestradiol twice daily for 5 to 7 days.
• To prevent heavy bleeding, Duphaston 5 mg twice daily from day 11 to 25 of the cycle, if necessary, combined with estrogen during the first half of the cycle.
• In post-menopausal complaints: If estrogens are used (hormone replacement therapy – HRT), Duphaston 10 mg is used to counteract the effects of unopposed estrogens on the endometrium, inducing withdrawal bleeding.
• If estrogen therapy is continuous: Duphaston 10 mg twice daily for the first 12 to 14 days of each calendar month.
• If estrogen treatment is cyclical: Duphaston 10 mg twice daily for the last 12 to 14 days of treatment.

What happens if I forget to take a dose?

There is no strict regimen for missed doses in the information provided. Consult your doctor or pharmacist if you have any questions.

What happens in case of an overdose?

See the sections on possible adverse effects and precautions. Treatment is symptomatic and supportive.

What should I avoid while taking Duphaston?

No specific precautions are indicated in the information provided on what to avoid during treatment, except for the contraindications and precautions described above.

What are the possible side effects of Duphaston?

• Gastrointestinal disorders.
• Allergic skin rashes or hives.
• Changes in libido.
• Acne.
• Fluid retention and increased body mass.
• Depression and mental changes, which may include discomfort or gynecomastia.
• Abnormalities in liver function tests, reported less frequently, including jaundice.

In a small percentage of cases, bleeding may occur, which can be prevented by increasing the dose.

No virilizing side effects were observed during clinical application of Duphaston.

What medications can interact with Duphaston?

Interactions with other medications can cause unwanted side effects or prevent a medicine from working properly.

Tell your doctor or pharmacist about all prescription and over-the-counter medications you are taking.

If you have any questions, always consult your doctor to make sure this medicine is right for you.